Role of IGF-1 signaling in the pathology of diabetic retinopathy
نویسندگان
چکیده
Faculty of Health Sciences, University of Macau, Taipa, Macau, China; and State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen UniversityGuangzhou 510060, China Department of Neuropharmacology, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, China Discipline of Pharmacy, School of Medical Sciences, RMIT University, Bundoora, Victoria 3083, Australia Department of Pharmacy, Xinhua College of Sun Yat-sen University, No. 721, Guangshan Road 1, Tianhe District, Guangzhou 510520, China
منابع مشابه
Genetic polymorphisms of glutathione-s-transferase M1 and T1 genes with risk of diabetic retinopathy in Iranian population
Objective(s):To the best of our knowledge, this is the first report on the contributions of GST genetic variants to the risk of diabetic retinopathy in an Iranian population. Therefore, the objective of this study was to determine whether sequence variation in glutathione S-transferase gene (GSTM1 and GSTT1) is associated with development of diabetic retinopathy in type 2 diabetes mellitus (T2D...
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Introduction: To compare the axial length of globe in patients with diabetic retinopathy with that in normal population and to evaluate its role in the progression of diabetic retinopathy. Methods: 150 patients with diabetic retinopathy in both eyes were compared with 150 age and sex matched non diabetic patients, referred to Motahari retina clinic of Shiraz, during fall 2000. The axial length...
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Single-gene disorders occur when mutation in a gene causing alteration of gene function while in multifactorial disorders, mutations occur in multiple genes, and these are usually coupled with environmental causes. In addition, in a multifactorial disorder such as diabetes, the complication is under the influence of different genes. For example, in diabetic retinopathy many genes are involved i...
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Background: The alteration of IGF-I systemic level in diabetes is typically characterized by depletion of free IGF-I plasma level and its decreased bioavailability. With regard to protective and advantageous effects of IGF-I on tissue healing and cellular regeneration such depletion could facilitate or accelerate tissue damages and complications. By contrast, the local concentration of IGF-I i...
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